For The Island of Dr. Moreau, a film about biological experiments and mad science, Prologue created an opening title sequence that was equally mad an evocative of science. Prologue used a montage of microbiotic organisms blended with strikes of lightning, giving the impression of life and the supernatural coming together similar to a story like Frankenstein. The unhinged nature of these experiments is reflected in the typography of the titles. Each credit frenetically twitches across the frame with jagged knife-life characters appearing occasionally. This sequence combines the science subject material of the narrative while injecting a suitable amount of mania to prepare the audience for the sci-fi and horror themes of the film.